Jason Glenn Parker1, Eric Zalusky1,
J. Lynn Caldwell2,
1Innovation Center, Kettering Health Network, Kettering, OH, United States; 2Human Effectiveness Directorate, Wright-Patterson AFB, Dayton, OH, United States; 3Research Institute, University of Dayton, Dayton, OH, United States; 4Siemens Medical Solutions, United States
Previous studies correlating changes in fMRI activation with sleep deprivation-induced cognitive impairment have assumed a linear increase in cognitive impairment over a period of sleep deprivation, but this method fails to model the nonlinear effects of circadian rhythm on cognition. In this work, we seek to use a latent growth curve analysis which models each individual subject's fatigue vulnerability profile using a 3rd order polynomial to correlate changes in brain activation and deactivation between rested wakefulness and 30 hours of sleep deprivation with cognitive impairment.