Aanandhi Venkatadri1, Sheryl L. Rimrodt2,3,
Amy Clements4, Kenneth R. Pugh5, Laurie E. Cutting6
1F.M.Kirby Center, Kennedy Krieger
Institute, Baltimore, MD, United States; 2Division of
Developmental Medicine, Children's Hospital of Vanderbilt, Nashville, TN,
United States; 3Department of Cognitive Neurology, Kennedy Krieger
Institute, Baltimore, MD, United States; 4Brain Sciences Institute
, Johns Hopkins University, Baltimore, MD, United States; 5Haskins
Laboratories, New Haven, CT, United States; 6Education and Brain
Research Laboratory, Vanderbilt University, Nashville, TN, United States
Reading
Disabled (RD) and Typically Developing Readers (TDR) were tested on a word
discrimination task using high and low frequency words and pseudowords. ANOVAs were used to analyze differences in
activation patterns between words versus pseudowords and between high versus
low frequency words. For low frequency
words, RDs showed greater activation than TDRs in right angular gyrus. For
pseudowords, RDs also showed greater activation than TDRs in left superior
temporal gyrus and several right hemisphere regions. Our findings suggest
modulation of neurobiological response depending on the type of words
presented; however, our findings also suggest that this modulation was
present regardless of the word imageability level.
Keywords