Hsiao-Ying Wey1,2, Timothy Q. Duong1,2
1Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States; 2Radiology, UT Health Science Center at San Antonio, San Antonio, TX, United States
Brains of large non-human primates are highly evolved with extensive gyrations that are most similar to humans compared to other species, resulting in better recapitulation of many human diseases compared to the more commonly used rodent models. This study compared the stimulus-evoked CMRO2 changes in baboons under isoflurane versus ketamine. Visual and somatosenory stimulations were employed. BOLD and CBF were measured simultaneously using the arterial-spin-labeling technique on a Siemens 3T TIM-Trio. Davis biophysical BOLD model was used to calculate CMRO2 changes via hypercapnic calibration. The comparisons of various physiological parameters were made between isoflurane and ketmaine anesthetics.