Marzena Wylezinska1, Jordi L. Tremoleda1, Jelena Anastasovska2, Willy Gsell1, Jimmy Bell2
1Biological Imaging Centre, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom; 2Metabolic Imaging Group, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom
The aim was to investigate the effect of high fat diet on myocardial triglyceride and function in preclinical model. Male C57/Bl6 mice were maintained on a high (21%) fat (HF n=6) or a normal (3%) fat diet (C, n=5). Using MRI left ventricular ejection fraction (LVEF) was measured, while localized 1H MRS was used to estimate lipids content in the interventricular septum in animals. Lipid content was significantly increased in HF group, while trend was observed in LVEF decrease in HF group. These preliminary results suggest that high fat diet may have implications on myocardial lipid content and cardiac function.