Left Ventricular Torsion in Hypertrophic Cardiomyopathy Mutation Carriers
with Normal Wall Thickness
Wessel Brouwer1, Tjeerd Germans1, Paul Knaapen1,
J Tim Marcus1, Jolanda van der Velden1, Marco Gtte1,
Albert van Rossum1
Center, Amsterdam, Netherlands
cardiomyopathy (HCM) is caused by mutations in mainly sarcomeric genes.
Increased left ventricular (LV)
torsion has been observed in patients with manifest hypertrophy, but
abnormalities in myocardial contractility might already be present in HCM
mutation carriers with normal wall thickness. Therefore, LV torsion and endocardial circumferential
strain were studied in HCM mutation carriers using MRI tagging. Increased LV torsion and torsion
to endocardial circumferential strain-ratio were found in carriers with
respect to controls. The observed difference might be due to HCM-related
endocardial myocardial dysfunction.