Sean Charles Forbes1, Sean Germain2, Nathan Bryant3, Glenn A. Walter3
1Department of Physical Therapy, University of Florida, Gainesville, FL, United States; 2Department of Pediatrics, University of Florida, United States; 3Department of Physiology and Functional Genomics, University of Florida, United States
Limb Girdle muscular dystrophy Type 2C is characterized by a deficiency in γ-sarcoglycan, a protein associated with the dystrophin-glycoprotein complex on the cell membrane. In this study, the effects of a lack of γ-sarcoglycan (Sgsg-/-) and dystrophin (mdx) on cardiac function and myocardium T2 in old mice were examined. The findings indicate that Sgsg-/- and mdx have a reduced left ventricular ejection fraction compared to age-matched controls, with no differences in Sgsg-/- and mdx. Also, a shorter T2 was observed in the myocardium of Sgsg-/- compared to controls, suggesting an increased prevalence of fibrosis in Sgsg-/-.