Bram F. Coolen1, Rik PM Moonen1, Leonie EM Paulis1, Tessa Geelen1, Larry de Graaf1, Klaas Nicolay1, Gustav J. Strijkers1
1Biomedical NMR, Department of
A method that allows myocardial first-pass perfusion measurements in mice is presented. Using a combination of segmented saturation-prepared FISP acquisition and GRAPPA parallel imaging allows a temporal resolution of one image every three heart beats with an acquisition time of less than 16 ms. First-pass perfusion images showed the influx of contrast agent into the myocardium with sufficient temporal resolution to derive semi-quantitative perfusion values. These were found significantly lower in a mouse with myocardial infarction compared to healthy control mice.