Andrea Protti1, Alexander Sirker1,
Xuebin Dong1, Marcelo Andia2, Ajay M. Shah1,
Rene Botnar2
1Cardiovascular Division, Kings
College London BHF Centre of Excellence, London, United Kingdom; 2Division
of Imaging Sciences, Kings College London BHF Centre of Excellence, London,
United Kingdom
In
this work, we sought to investigate the merits of a very small
superparamagnetic iron oxide particle (VSOP) for direct imaging of
inflammation in a mouse model of MI and to quantify T2* using multi echo
gradient echo images. The combined use of a very small iron-oxide particle,
VSOP, and the use of short to long TE acquisition to generate T2* mapping
allowed the quantitative assessment of VSOP uptake in the infarct zone.