William Lefranois1, Sylvain Miraux, Guillaume Calmettes, Franois Vigneron2, Jean-Michel Franconi, Philippe Diolez, Eric Thiaudire
1Rsonance Magntique des Systmes Biologiques, UMR 5536 CNRS-Univ. Bordeaux 2, Bordeaux, Gironde, France, Metropolitan; 2INSERM U828, Avenue du Haut Lvque, Bordeaux, France
This study aimed to develop a new method enabling a fast time-resolved cine 2D and cine 3D (4D) black blood imaging of mouse heart. This sequence has been applied to Manganese-Enhancement MRI (MEMRI) studies i.e. with Mn2+ infusion to improve contrast. This new method provided time- and space-resolved 3D images, respectively (200 m) 3 and one image every 12 ms, for the first time within 30 minutes only. Lastly, associated to manganese infusion, this sequence appeared to be particularly adequate for studying cardiac pathologies such as ischemia on animal models.