Rajesh Dash1, Jaehoon Chung1,
Yuka Matsuura1, Fumiaki Ikeno1, Jennifer Lyons1,
Tomohiko Teramoto1, Alan C.Y. Yeung1, Michael V.
McConnell1,2, Todd J. Brinton1, Phillip Harnish3,
Phillip C. Yang1
1Division of Cardiovascular Medicine, Stanford
University Medical Center, Stanford, CA, United States; 2Department
of Electrical Engineering, Stanford University , Stanford, CA, United States;
3Eagle Vision Pharmaceutical Corporation, Exton, PA, United States
Manganese-enhanced
MRI (MEMRI) detects Mn2+ uptake into viable cells, a distinct
mechanism from gadolinium delayed enhancement MRI (DE-MRI). We tested whether combined DE-MRI plus
MEMRI would delineate peri-infarct border zone injury in a pig
ischemia-reperfusion (IR). Pigs were
imaged by cardiac MRI 3 weeks post-IR.
3D DE-MRI scar volume correlated with histopathologic scar volume, but
MEMRI scar volume was significantly smaller than DE-MRI scar volume. The
border zones of DE-MRI scar, which were also positive by MEMRI, showed
decreased SNR compared to remote zone MEMRI SNR. Combined MEMRI and DE-MRI may identify
injured border zone myocardium in ischemic cardiomyopathy.