Rajesh Dash1, Jaehoon Chung1, Yuka Matsuura1, Fumiaki Ikeno1, Jennifer Lyons1, Tomohiko Teramoto1, Alan C.Y. Yeung1, Michael V. McConnell1,2, Todd J. Brinton1, Phillip Harnish3, Phillip C. Yang1
1Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA, United States; 2Department of Electrical Engineering, Stanford University , Stanford, CA, United States; 3Eagle Vision Pharmaceutical Corporation, Exton, PA, United States
Manganese-enhanced MRI (MEMRI) detects Mn2+ uptake into viable cells, a distinct mechanism from gadolinium delayed enhancement MRI (DE-MRI). We tested whether combined DE-MRI plus MEMRI would delineate peri-infarct border zone injury in a pig ischemia-reperfusion (IR). Pigs were imaged by cardiac MRI 3 weeks post-IR. 3D DE-MRI scar volume correlated with histopathologic scar volume, but MEMRI scar volume was significantly smaller than DE-MRI scar volume. The border zones of DE-MRI scar, which were also positive by MEMRI, showed decreased SNR compared to remote zone MEMRI SNR. Combined MEMRI and DE-MRI may identify injured border zone myocardium in ischemic cardiomyopathy.