Pierre-Julien Moro1,2, Alexis Jacquier1, Frank Kober1, Jean-Louis Bonnet2, Patrick Cozzone1, Monique Bernard3
1Centre de Rsonance Magntique Biologique et Mdicale, CNRS UMR 6612, Universit de la Mditerrane, Facult de Mdecine, Marseille, France; 2Cardiology, CHU Timone, Marseille, France; 3Centre de Rsonance Magntique Biologique et Mdicale, CNRS UMR 6612, Universit de la Mditerrane , Facult de Mdecine, Marseille, France
The purpose of this study was to assess a non invasive measure of coronary endothelial function. Coronary sinus flow was measured in 14 volunteers at rest and during cold pressor test (CPT) using non breath-hold velocity encoded phase contrast cine MRI. Myocardial blood flow (MBF) significantly increased by 55 38 % during CPT compared to the rest examination (p<0.0001); coronary blood flow was 0.66 0.22 ml/min/g at baseline and 1.03 0.41 ml/min/g after CPT. This non invasive measure may help to detect changes in endothelial function which occur early in a variety of cardiovascular diseases.