Ramona Lorenz1, Christoph Benk2, Jelena Bock1, Jan Korvink3, Michael Markl1
1Dept. of Diagnostic Radiology, University Hospital, Freiburg, Germany; 2Dept. of Cardiovascular Surgery, University Hospital, Freiburg, Germany; 3Dept. of Microsystems Technology, IMTEK, Freiburg, Germany
In-vitro model systems provide a useful tool for the systematic evaluation of hemodynamic changes associated with geometric vascular modifications. However, realistic in-vivo in-flow and boundary conditions are necessary for accurate flow simulations. This paper presents a novel approach for an in-vitro model setup which includes a pulsatile pump chamber in combination with flexible and monitored pressure control using an adjustable mock loop to simulate physiological pre- and after load conditions. In contrast to measurements without pressure control an improved generation of qualitative and quantitative flow characteristics compared to in-vivo flow conditions could be achieved.