John David Biglands1, Abdulghani Larghat1,
Sven Plein1, David L. Buckley1, Michael Jerosch-Herold2,
Derek Magee3, Roger Boyle3, Aleksandra Radjenovic1
1School of Medicine, University of
Leeds, Leeds, UK, United Kingdom; 2Radiology, Brigham and Womens
Hospital, Boston, MA, United States; 3School of Computing,
University of Leeds, Leeds, United Kingdom
Dynamic
contrast enhanced magnetic resonance imaging of the myocardium using
sufficiently high doses to be clinically useful generates uptake curves that
require correction for signal saturation effects before they can be used for
myocardial blood flow (MBF) estimation.
Such corrections require knowledge of the native T1 of the blood and
myocardium. This abstract shows that using
an assumed blood T1 enables saturation correction of typical clinical datasets
without the need for time consuming T1 measurements. MBF estimates from nine patients were
consistent with literature values and were shown to be robust to variations
in the assumed T1 of blood.