James W. Goldfarb1,2, Wenguo Zhao1
1Saint Francis Hospital, Roslyn, NY,
United States; 2Program in Biomedical Engineering, Stony Brook
University, Stony Brook, NY, United States
The
purpose of this study was to investigate the temporal dynamics a
two-compartment tissue-blood partition coefficient and compare it to
estimates using a three-compartment model.
In 25 individuals with chronic myocardial infarctions, blood
Gd-concentration was modeled with a bi-exponential and myocardial tissue
Gd-concentration with a three-compartment model. It was found that the measurement of the
tissue-blood partition coefficient based on the ratio of T1 relaxation time
differences is time dependent.. The measurement of the tissue-blood partition
coefficient using a three compartment model yields similar values between
infarcted and viable myocardium. T1 relaxation differences are likely due to
a third trapping compartment.