Xiuling Qi1, Aaron Teitelbaum1, Kevan Anderson1, Nigel Munce1, Beiping Qiang1, Ronen Jaffe1, Michelle Ladouceur-Wodzak1, Bradley H. Strauss1, Graham A. Wright1
Synopsis: Revascularization in an arterial chronic total occlusion (CTO) could improve the prognosis. We evaluated the effect of injecting vascular endothelial growth factor (VEGF) into a CTO in a femoral artery of rabbit using in vivo MRI and ex-vivo micro-CT. Thirteen rabbit were divided randomly into control and VEGF groups. The blood volume changes in CTO pre and post interventions were determined. Results indicated by both MRI and micro-CT that the VEGF significantly increased the formation of microvessels within CTO. Our study also demonstrated that MRI is a feasible method to assess the new blood vessel growth in CTO tissue.