Nelly A. Volland1, Thomas H. Mareci2,3,
Nicholas E. Simpson4
1Radiology, University of Utah, Salt
Lake City, UT, United States; 2Biochemistry and Molecular Biology,
University of Florida, Gainesville, FL, United States; 3McKnight
Brain Institute, University of Florida, Gainesville, FL, United States; 4Medicine,
University of Florida, Gainesville, FL, United States
Introduction:
Uniform excitation and highly sensitive signal detection is necessary for
optimal MRS of bioartificial constructs, particularly when determining
function. Methods: Receive-only
implantable coils were constructed, coated, and integrated with the
macroconstruct. This assembly was
inductively-coupled to an external coil and tested in vitro in combination
with a transmit-only volume coil at 11.1T.
Results: Studies showed small overall gains in SNR with this system
under loaded conditions over a transmit-receive system, and greater signal
uniformity. Conclusion: A receive-only
implantable coil system was successfully built and tested. This system will allow for superior
quantitative monitoring of implanted bioartificial organs.