Cornelius von Morze1, Douglas A. Kelley2, Suchandrima Banerjee2, Timothy M. Shepherd1, Duan Xu1, Christopher P. Hess1
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2GE Healthcare, San Francisco, CA, United States
Ventral regions of the brain are an important research target in the early detection of Alzheimers disease, but standard single shot EPI diffusion weighted imaging of these areas at 7T is contaminated by severe imaging artifacts. To reduce these, we investigated a combination of reduced FOV acquisition, enabled by outer volume suppression with custom designed quadratic phase RF pulses, with existing parallel imaging and partial Fourier methods. The reduced FOV diffusion acquisition greatly reduced the level of artifacts in five human subjects (including four patients with early symptoms of dementia).