Matthan W.A. Caan1,2, M. M. van der Graaff1, S. D. Olabarriaga1, C. A. Grimbergen1, L. J. van Vliet2, F. M. Vos1,2
1Radiology, Academic Medical Center, Amsterdam, North-Holland, Netherlands; 2Imaging Science and Technology, Delft University of Technology, Delft, Netherlands
In Diffusion Weighted MRI, the diffusion weighting should be high enough to facilitate fiber tracking through crossings. We propose to estimate a dual tensor model on an entire cohort with low diffusion weighting and a limited number of gradient directions. Diffusion attenuation profiles of multiple subjects are regarded as realizations of a single underlying fiber distribution. Non-rigid coregistration ensures spatial correspondence. Increased angular resolution is ensured by random subject positioning in the scanner, as well as by anatomical heterogeneity. In our dual tensor atlas, we tracked fibers which proceeded contralaterally through the decussation of the superior cerebellar peduncle.