Edward S. Hui1,2, Steve H. Fung2,3, Ed X. Wu1,4
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong; 2Department of Radiology Research, The Methodist Hospital Research Institute, Houston, TX, United States; 3Department of Radiology, Weill Medical College of Cornell University, New York, United States; 4Department of Electrical & Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong
As diffusion-weighted (DW) signal attenuation not only depends on diffusion gradient strength but also the time separation between the 2 diffusion gradients (Δ), it is important to examine the effect of Δ on the kurtosis of the water displacement profile which could be estimated by a recently proposed robust and efficient technique known as diffusion kurtosis imaging (DKI). It quantifies the kurtosis of the water diffusion profile, by acquiring DW signal at multiple b-values by varying the diffusion gradient strength at fixed Δ. The effect of Δ on kurtosis has been studies in vivo for the first time to assess its potential in teasing biological information underlying neural microstructures.