Miia Pitkonen1, Aysan Durukan2, Eric Pedrono3, Ivan Marinkovic2, Turgut Tatlisumak2, Usama Abo-Ramadan4
1Biomedicum Helsinki, Experimental MRI laboratory , Helsinki, Finland; 2Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland; 3Biomedicum Helsinki, Experimental MRI Laboratory, Helsinki, Finland; 4Biomedicum Helsinki, Experimental MRI Laboratory, Helsinki, Finland
Diffusion tensor imaging can approximates the linear, planar, and tubular tensor using CL, CP, and CS. We want to characterize the evolvement of these indices following brain ischemia. We followed the evolvement of these indices in 3 cortex, subcortex, and corpus callosum. Following brain ischemia, no such systematic approach over an extended period of time, with CL, CP, and CS, has not yet been reported. Wistar rats were subjected to focal cerebral ischemia by transient suture occlusion (n = 9). They were imaged in the hyperacute (2 and 3.5 hours), acute (1, 2, and 3 days), subacute (4 days, 1, and 2 week), and in the chronic phase (4, 6, and 8 weeks) after the MCAO. The MRI measurements were performed with a 4.7 T MR Scanner. Following acute ischemia, indices indicated damage in the neuronal cell bodies and in the chronic ischemic tissue possible recovery.