Simone Chaudhary1,2, Rafal Janik1, Amy Scouten1, Adrienne Dorr1, Wayne Lee3, Graeme Schwindt1, Sandra Black1, John Sled3, Bojana Stefanovic1
1Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 3Hospital for Sick Children, Toronto, Ontario, Canada
A number of neurodegenerative diseases are characterized by compromised cerebral hemodynamics. Cerebral blood flow (CBF) and arterial transit time have been mapped in healthy elderly, MCI, and AD via pulsed continuous ASL at varying inversion times. Two compartment theory was employed in the analysis. MCI showed a trend toward decreased CBF relative to healthy volunteers, whereas AD was associated with a pronounced, statistically significant hypoperfusion. Arterial transit time decreases suggested compensatory vasodilation in a subset of subjects.