Adolf Pfefferbaum1,2, Ajit Shankaranarayanan3, David Alsop4,5, Sandra Chanraud, 1,2, Anne-Lise Pitel2, Torsten Rohlfing1, Edith V. Sullivan2
1Neuroscience Program, SRI International, Menlo Park, CA, United States; 2Psychiatry&Behavioral Sciences, Stanford University, Stanford, CA, United States; 3MR Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 4Radiology, Harvard Medical School, Boston, MA, United States; 5Radiology, Beth Israel Deaconess Medical Center, Boston, m, United States
The regional distribution, laterality and reliability of volumetric arterial spin labeling (ASL) measurements of CBF in cortical, subcortical, and cerebellar regions was determined in normal volunteers. Regional CBF, normalized for global perfusion, was highly reliable when measured on separate days. There was considerable regional variability and several regions of significant lateral asymmetry. The posterior cingulate cortex had the highest perfusion and the globus pallidus the lowest, may be due to iron-induced signal attenuation. High rCBF in the posterior cingulate cortex in this task-free acquisition is consistent with its identification as a principal node of the "default mode network."