John Robert Cain1, Samantha J. Mills1,
Alan Jackson1, Laura M. Parkes1,2
1Imaging Science, University of
Manchester, Manchester, United Kingdom; 2Biomedical Imaging
Institute, University of Manchester, Manchester, United Kingdom
Four
healthy subjects (aged 24-29) underwent MRI imaging, inhaling 100% O2,
medical air and carbogen gas (95%O2 5%CO2). Imaging
consisted of STAR ASL sequence followed by a PCA acquisition under each gas.
CBF values were higher during carbogen inhalation compared to medical air
with both PCA and ASL. 100% O2 CBF results were not significantly
different from medical air using both methods but the difference between the
ASL label and control signal (ΔM) was decreased compared to medical air
and increased during CO2 inhalation. ASL was able to detect
changes in CBF with equal precision to PCA CBF measurements.