Andrew B. Holbrook1,2, Chuck L. Dumoulin3, Juan M. Santos4,5, Yoav Medan6, Kim Butts Pauly2
1Bioengineering, Stanford University, Stanford, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Imaging Research Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States; 4HeartVista, Los Altos, CA, United States; 5Electrical Engineering, Stanford University, Stanford, CA, United States; 6InSightec Ltd, Tirat Carmel, Israel
We have developed an integrated MRI and high intensity focused ultrasound (HIFU) real time system. The system allows for both flexible control and monitoring of both systems, from device localization utilizing MR tracking to treatment planning and therapy monitoring utilizing MR thermometry pulse sequences. Additionally, the software allows for prescription of complex sonication spots, including treatment paths and regions. The system was tested both in a phantom and in vivo to assess its effectiveness in guiding HIFU therapy. Prescribed treatment plans were achieved in both experiments.