Mie Kee Lam1,2, Taku Iwabuchi1, Kensuke Saito1, Kagayaki Kuroda3,4
1School of Engineering, Tokai University, Hiratsuka, Kanagawa, Japan; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Graduate School of Engineering, Tokai University, Hiratsuka, Kanagawa, Japan; 4Medical Device Development Center, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, Japan
Numerical simulations were performed to investigate the effect of thermal shift of water proton resonance on the accuracy of methylene T1 estimation for fat temperature quantification with multiple flip angle, multipoint Dixon acquisitions and a least square estimation scheme. The performance of separating methylene and methyl, and estimating T1's of those species were successful as far as the frequency separations between those species and water was exact. The results with incomplete setting of the frequency separations showed that the error in methylene T1 would be controlled and an accuracy of 4C can be achieved by adjusting the separation within an error of 0.05 ppm.