Cory Robert Wyatt1, Brian J. Soher2, James R. MacFall2
1Department of Biomedical Engineering, Duke University, Durham, NC, United States; 2Department of Radiology, Duke University Medical Center, Durham, NC, United States
Proton resonance frequency shift (PRFS) thermometry of the breast is often confounded not only by the presence of fat in the tissue but also by respiration-induced B0 changes even in the absence of detectable breast motion. In this work, field fitting techniques used previously are used to extrapolate fat referenced B0 changes measured using fat-water separation methods to B0 changes in a water-only simulated tumor in a fat-water breast phantom. Results show that the B0 map extrapolation method reduces PRFS temperature errors between breath holds from a maximum of 5.55C to less than 0.53C.