Cory Robert Wyatt1, Brian J. Soher2,
James R. MacFall2
1Department of Biomedical Engineering,
Duke University, Durham, NC, United States; 2Department of
Radiology, Duke University Medical Center, Durham, NC, United States
Proton
resonance frequency shift (PRFS) thermometry of the breast is often
confounded not only by the presence of fat in the tissue but also by
respiration-induced B0 changes even in the absence of detectable breast
motion. In this work, field fitting
techniques used previously are used to extrapolate fat referenced B0 changes
measured using fat-water separation methods to B0 changes in a water-only
simulated tumor in a fat-water breast phantom. Results show that the B0 map
extrapolation method reduces PRFS temperature errors between breath holds
from a maximum of 5.55C to less than 0.53C.