Maythem Saeed1, David Saloner1, Phillip Ursell2, Loi Do1, Mark Wilson1, Alastair J. Martin1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States; 2Pathology, University of California San Francisco, San Francisco, Ca, United States
It is unknown whether MR-guided transendocardial delivery of hepatocyte growth factor gene (HGF) is effective in ameliorating LV remodelling. XMR suite (x-ray cath-lab and a 1.5T MR scanner) for real-time imaging, transendocardial delivery and assessing the gene effects in swine with remodelled LV. Six MR sequences were used for evaluation of the efficacy of therapy. MR-guided transendocardial delivery of HGF a) ameliorated global function and 3D strain, b) activated perfusion, neovascularization and myogenesis in scar and c) reduced infarct. The combination of this therapy and XMR technique may be useful in patients with ischemic myocardium and cell loss (apoptosis).