H. Douglas Morris1, James P. Sumner2
1NIH Mouse Imaging Facility, National Institues of Health, Bethesda, MD, United States; 2Laboratory of Functional and Molecular Imaging, National Institues of Health, Bethesda, MD, United States
MRI has become a potent method for tracking cells in situ and in vivo. Recent techniques can produced endogenously labeled cells that can be for tracking cellular migration. A complication is the presence of a large amount of magnetic particle label, which adversely affects high-efficiency pulse sequences such as balanced SSFP. The worst off-resonance artifacts can be mitigated by using a linear combination of SSFP sequences (LCSSFP), which can reduce the artifacts produced by these label caches while preserving the effect detection of the labeled cells.