Yuanxin Chen1, Jian-Xiong Wang2, Lisa M. Gazdzinski1, Paula J. Foster1, Brian K. Rutt3
1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Applied Science Laboratory, GE HEALTHCARE, London, Ontario, Canada; 3Department of Radiology, Stanford University, Stanford, CA, United States
There has been increased interest in positive-contrast MRI methods to visualize cells labeled with superparamagnetic iron oxide (SPIO) nanoparticles. Here, we applied the 3D Cones technique for ultra-short echo time (UTE) imaging of SPIO-labelled tumour cells in mouse brain. An intracranial tumour model was created by injection of SPIO labeled GL261 mouse glioma cells into the striata of C57/Bl6 mice. Short-T2-selective UTE imaging with a 3D Cones sequence on a 1.5T MR scanner was accomplished through the subtraction of interleaved, alternating-TE data acquired in an RF-TE1-RF-TE2 scheme. This work shows the feasibility of selectively tracking SPIO-labeled cells with positive-contrast.