Vt Herynek1,2, Zuzana Berkov3, Daniel Hork4, Michal Babic4, Daniel Jirk1,2, Frantiek Saudek3, Milan Hjek1
1MR-Unit, Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Center for Cell Therapy and Tissue Repair, Second Medical Faculty, Charles University, Prague, Czech Republic; 3Pancreatic Islet Laboratory, Diabetology Clinic, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 4Institute of Macromolecular Chemistry, Czech Republic
Visualization of transplanted islets using MRI requires labeling of islets by a suitable contrast agent. We successfully tested alternative superparamagnetic iron oxide nanoparticles with improved biological and physical properties, which represent alternative to commercially available dextran coated contrast agents. Modified coating of the nanoparticles ensures higher efficiency at lower concentrations and no adverse effects on islet viability or insulin secretion.