Yuting Lin1, Mehmet B. Unlu1, Brian Grimmond2, Anup Sood2, Egidijus E. Uzgiris3, David Thayer1, Han Yan1, Orhan Nalcioglu1, Gultekin Gulsen1
1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2GE Gobal Research, Niskayuna, NY, United States; 3Rensselaer Polytechnic Institute,, Troy, NY, United States
Multi-modality imaging is becoming a trend in developing new generation in vivo imaging techniques for diagnosis. Recently, our group has developed a high temporal resolution dynamic MRI/DOT multi-modality imaging system. In such a multi-modality system, each modality measures a different parameter set, which make it difficult to cross-validate the parameters measured by different modalities. An alternative solution is using a bi-functional contrast agent that provides contrast for both optical and MRI simultaneously. Here, our in vivo small animal study is the first to validate a true multi-modality system with a true multi-modality contrast agent.