Snke H. Bartling1, Johannes Budjan1, Hagit Aviv2, Henrik J. Michaely1, Wolfhard Semmler3, Stefan O. Schnberg1, Steffen Diehl1, Shlomo Margel2, Maliha Sadick1
1Clinical Radiology and Nuclear Medicine, University Medical Center, Mannheim, Baden-Wrttemberg, Germany; 2Dept. of Chemistry, Bar-Ilan University, Ramat-Gan, Israel; 3Dept. of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
MRI guidance of interventions is a goal. Current embolization particles cannot be detected by an imaging modality (clinical) or only by CT/X-ray (research). Here, we developed and tested the first multimodal embolization particles being visible within MRI and CT/x-ray. An animal model was used. Post embolization imaging confirmed dual-modality contrast as embolized areas could be detected by CT and MRI. Histology confirmed results. The particles consist of two clinically approved substances: polymerized Iodine and USPIO. Once introduced into clinical routine, improvements of embolization therapy can be expected, because both CT and MRI could be used for treatment control.