Julio Acosta-Cabronero1, George Pengas2, Guy B. Williams1, Peter J. Nestor2
1Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
The diffusion profile in semantic dementia (SD) was studied to examine the profile of connection changes. Tract-based spatial statistics in SD patients provided compelling evidence that the network is distinct to that of Alzheimers disease (AD), and indicated that the key abnormality exiting the temporal lobe was in the uncinate fasciculus projection to the orbital frontal lobe. The tensor behaviours also indicated that the nature of the neurodegenerative in SD differs qualitatively from that seen in AD.