Sumei Wang1, Sungheon Kim2, Sanjeev Chawla1, Ronald L. Wolf1, David Knipp1, Arastoo Vossough1, Donald M. ORourke3, Kevin D. Judy3, Elias R. Melhem1, Harish Poptani1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Radiology, New York University School of Medicine, New York, NY, United States; 3Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States
Twenty-six glioblastomas, 25 brain metastases and 16 cerebral lymphomas underwent DTI and DSC studies. FA, ADC, CL, CP, CS and rCBV were measured from the enhancing part of the tumor. Elevated FA, CL, CP and decreased CS were observed in glioblastomas compared with both metastases and lymphomas, whereas ADC and rCBV values from glioblastomas were significantly higher than lymphomas. FA and ADC was the best predictor for differentiation of glioblastomas from non-glioblastomas, whereas ADC, CS and rCBV were the best model for distinguishing lymphomas from metastases. Our study indicates that DTI metrics along with rCBV measurement may be helpful in tumor classification.