Heisoog Kim1,2, Ciprian Catana1, Grace Kim1, Ovidiu C. Andronesi1, Dominique L. Jennings1, Divya S. Bolar1,3, Elizabeth R. Gerstner4, Tracy T. Batchelor4, Rakesh K. Jain5, Alma Gregory Sorensen1
1A.A.Martinos center, Massachusetts General Hospotal, Charlestown, MA, United States; 2NSE/HST, Massachusetts Institute of Technology, Cambridge, MA, United States; 3EECS/HST, Massachusetts Institute of Technology, Cambridge, MA, United States; 4Neurology, Massachusetts General Hospotal, Boston, MA, United States; 5Radiology, Massachusetts General Hospotal, Boston, MA, United States
This study quantitatively investigated BOLD responses to pure oxygen in glioblastoma (GBM) throughout the course of the treatment with chemoradiation and an anti-angiogenic drug. BOLD signal changes dropped significantly at the beginning of the treatment in tumor and gradually recovered afterwards. Conversely, in contralateral normal tissue a slight increase was observed at the early time points. Interestingly, no difference was observed between values in both regions after 35 days. Our preliminary findings suggest that assessing the oxygenation status before and after treatment might be useful for both prognostic and diagnostic assessment in GBM patients.