Bing Yao1, Simon Hametner2, Peter van Gelderen1, Hellmut Merkle1, Fredric Cantor3, Henry McFarland3, Hans Lassmann2, Jeff H. Duyn1, Francesca Bagnato3
1AMRI, NINDS, National Institutes of Health, Bethesda, MD, United States; 2Centre for Brain Research, Medical University, Vienna, Austria; 3NIB, NINDS, National Institutes of Health, Bethesda, MD, United States
Focal cortical grey matter lesions (CLs) are an important component of multiple sclerosis (MS) pathology. However, detecting cortical lesions in MS using MRI poses challenges. MRI at ultra-high field strengths such as 7 Tesla has the potential to superbly enhance MS-induced CLs visibility. In this study, we applied ultra-high resolution R2* maps to detect and evaluate cortical lesions and their subtypes and the MRI results were compared with the pathology analysis.