Jennifer Elizabeth Dixon1, Matthew John Brookes1, Emma C. Tallantyre2, Nikos Evangelou2, Peter G. Morris1
1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Department of Clinical Neurology, Nottingham University Hospital NHS Trust, Nottingham, Nottinghamshire, United Kingdom
Post-mortem studies of MS lesions show a close spatial relationship to parenchymal veins. In vivo study of this has previously been limited by the difficulties in demonstrating both lesions and veins on a single MR image. Recently, we have shown that T2*-weighted MRI at 7T enables simultaneous visualisation of both structures, and found that 82% of white-matter MS lesions contained a detectable vein. Here, we predict optimal scanning parameters for increasing the sensitivity of vessel detection and reducing the inherent bias towards detection of veins with particular orientations.