Francesca Bagnato1, Clelia Pellicano1, Fredric Cantor1, Antonio Gallo1, Sungyoung Auh2, Mary Ehrmantraut1, Iordanis Evangelou1, Vasiliki Ikonomidou1, Robert Kane3, Joan Ohayon1, Susan Stern1, Henry McFarland1
1NIB-NINDS-NIH, Bethesda, MD, United States; 2Clinical Director Office-NINDS-NIH, Bethesda, MD, United States; 3VA, Baltimore
Pathophysiological mechanisms underlying the development of depression in patients with multiple sclerosis (MS) remain unknown. We here demonstrate that atrophy of deep grey matter (GM) structures of the limbic circuit, such as thalamus and hippocampus, may explain up to 30% of the variance of depression in MS. The relation between depression and GM atrophy holds significant when the effect of patients physical disability is taken into account. The results highlight the role of neurodegeneration in specific brain sites as an important factor associated with depression in MS patients.