Virginia F. Newcombe1,2, Jo G. Outtrim1, Dot A. Chatfield1, Anne Manktelow1, Peter J. Hutchinson3, Jon P. Coles1,2, Guy B. Williams2, Barbara Sahakian4, David K. Menon1,2
1Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3Academic Department of Neurosurgery, University of Cambridge, Cambridge, United Kingdom; 4Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Impairment in decision making is commonly impaired post TBI contributing to the burden on healthcare systems worldwide. Diffusion tensor imaging (DTI) in selected ROIs was correlated with neurocognitive performance in a decision making task, the Cambridge Gambling Task; CGT. Cognitive performance on neuropsychological testing correlated significantly with diffusivity parameters in cognate brain regions. Our data add to the evidence that loss of microstructural integrity, as detected by DTI, is an important determinant of function following TBI, and confirm the involvement of key neurochemical networks in these complex neurocognitive tasks. DTI may be a useful research and clinical tool in this setting.