Richa Trivedi1, H Anuradha2, Atul Agarwal2, Ram KS Rathore3, Kashi N. Prasad4, Rajendra P. Tripathi1, Rakesh Kumar Gupta5
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Neurology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Mathematics and Statistics, Indian Institute of Technology, , Kanpur, Uttar Pradesh, India; 4Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Diffusion tensor tractography using FACT algorithm was performed on 20 children with different grades of subacute sclerosing panencephalitis (SSPE) to look for probable correlation between tract-specific DTI metrics in major white matter pathways and Jabbour classification based clinical grades. A significant inverse correlation was observed between fractional anisotropy (FA) in major white matter tracts and clinical grades. We conclude that FA is a better measure than conventional MRI for the assessment of clinical grade in these patients.