Junya Konishi1,2, Julien Milles2,
Jeroen van der Grond2, Mark A. van Buchem2
1Department of Radiology, Kobe
University Graduate School of Medicine, Kobe, Japan; 2Department
of Radiology, Leiden University Medical Center, Leiden, Netherlands
MRI
manifestations of cerebral amyloid angiopathy (CAA) are white matter
hyperintensities (WMH) and cerebral micobleeds (CMB), and the characteristics
of CAA-related WMH have not been studied before. The purpose of this study
was to study the volume and distribution of CAA-related WMH using an
automated method for probability maps and voxelwise statistical maps of WMH
on MRI. Our study demonstrated that CMB are associated with WMH, and
increased numbers are associated with increased volumes of WMH. Also we found
evidence for differences in distribution of WMH associated with CAA-type CMB
as compared to other types of CMB.