Federica Agosta1, Stefania Sala1, Elisabetta Pagani1, Domenico Caputo2, Massimo Filippi1
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy; 2Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy
Linear and quadratic age-related WM tract microstructural and volumetric changes were evaluated in 84 healthy volunteers. Age-related MD increase and FA decrease were associated with region-specific patterns of radial diffusivity increase and both decrease and increase in axial diffusivity. The quadratic model better fitted DT-MRI changes in several WM tracts. A negative correlation was found between age and left cingulum and fornix volumes. The quadratic model better fitted volume decline in corpus callosum and right inferior-fronto-occipital fasciculus. WM integrity loss and atrophy varies with age by WM tract and may reflect different degrees of severity of changes in WM properties.