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Abstract #4361

Assessing the Corticospinal Tract with Multimodal Quantitative MRI

Pierre-Yves Herve1, Eleanor F. Cox2, Ashley Loftipour2, Olivier Mougin2, Sam Wharton2, Richard W. Bowtell2, Tomas Paus1, Penny A. Gowland2

1Brain & Body Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2SPMMRC, Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom


The study of human white matter fibre pathways was first performed on post-mortem material, notably via dissection or with the Weigert staining method for myelinated fibres (Dejerine, 1895). More recently, diffusion weighted imaging emerged as a non-invasive alternative for both the tracing and the measurement of quantitative parameters of fibre pathways. Here we use multimodal quantitative imaging to assess differences between white matter structures.