Wei Gao1, Hongtu Zhu2, John Gilmore3, Weili Lin4
1Biomedical Engineering, UNC-Chapel Hill, Chapel Hill, NC, United States; 2Biostatistics and Biomedical Research Imaging Center, University of North Carolina-Chapel Hill; 3Psychiatry, University of North Carolina-Chapel Hill; 4Radiology and Biomedical Research Imaging Center, University of North Carolina-Chapel Hill
The integrated action between functionally connected yet spatially distributed regions to form different modules is central to normal brain function. Numerous studies have been performed to detect possible brain modules supporting specific functions including sensory processing and the higher level cognition in adults. However, the formation of modular structures is likely to be substantially influenced by both structural maturation and learning, particularly during the early stage of brain development. In this study, healthy pediatric subjects 2 wks to 2 yrs of age were recruited and modularity analysis was performed to discern whole brain functional networks so as to delineate the emerging and developing trajectory of brain modular structures in a critical time period of early brain development.