Jeffrey A. Stanley1, Dalal Khatib1,
Rachel M. Dick1, Olivia A. McGarragle1, Frank P.
MacMaster1, Arthur L. Robin1, David R. Rosenberg1,
Brian Martis2, Vaibhav A. Diwadkar1
1Psychiatry and Behavioral
Neurosciences, Wayne State University School of Medicine, Detroit, MI, United
States; 2Psychiatry, VA Ann Arbor HCS, University of Michigan, Ann
Arbor, MI, United States
The
high prevalence of the onset of many psychiatric disorders during childhood
and adolescence highlights the importance of understanding the molecular
biochemistry of healthy neurodevelopmental trajectories in the maturing
brain. In vivo 31P
spectroscopy is a neuroimaging method that is sensitive in detecting
biochemical changes as the brain develops. The purpose of this study is to
investigate changes in membrane phospholipid metabolites of healthy children
and adolescents to discern developmental growth spurts in cortical and
subcortical structures using in vivo
31P spectroscopy at a higher magnetic field strength.