Wilburn E. Reddick1, Qing Ji1, David C. Carver1, John O. Glass1, Jun-Yu Guo1, Zoltan Patay2
1Division of Translational Imaging Research, St. Jude Children's Research Hospital, Memphis, TN, United States; 2Division of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States
We investigated the feasibility and utility of performing DTI (FA, Dradial) and multi-exponential T2 relaxation imaging (MWF, long-T2) to assess differing degrees of myelin disruption early in the course of therapy for ALL in two 4 year old patients with varying degrees of leukoencephalopathy. Relatively low FA, increased Dradial, and decreased MWF were evident in regions of the T2 hyperintensities. Long-T2 maps demonstrated that one patient had more sever myelin and axonal damage than the other patient. This study is the first to conduct DTI and multi-exponential T2 relaxation imaging during ALL therapy and provides support for additional prospective studies.