Miyuki Takasu1, Chihiro Tani1, Masaki Ishikawa1, Keizo Tanitame1, Hiroshi Fukuda1, Jun Horiguchi1, Akihisa Tamura2, Yoshikazu Nishi3
1Radiology, Hiroshima University Hospital, Hiroshima, Japan; 2Radiology, Hiroshima Red Cross Hospital, Hiroshima, Japan; 3Pediatrics, Hiroshima Red Cross Hospital, Hiroshima, Japan
We investigated correlations between pituitary volumes measured from 3D volumetric MR imaging and the severity of the clinical and biochemical features in 69 patients with growth hormone deficiency. Pituitary volumes of all patient groups were smaller than the age-matched published norms. Pituitary volumes of both female groups were significantly smaller than that of controls. Pituitary volumes of male pubertal or postpubertal group were significantly larger than that of prepubertal one, but this difference was not significant between female groups. IGF-1 levels were significantly correlated with pituitary volumes. LH levels were significantly correlated with pituitary volumes in male patients.