Hongyu An1, Andria Ford2, Cihat Eldeniz1, Katie Vo2, Rosana Ponisio2, Yasheng Chen1, William Powers1, Jin-Moo Lee2, Weili Lin1
1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; 2Washington University in St. Louis, St. Louis, MO, United States
Spatial heterogeneity of tissue perfusion change was detected in acute patients after tPA treatment. Concurrent development of reperfusion and new hypoperfusion were observed. Compared to the reperfused region, the nonreperfused region had a significantly greater MTT prolongation, suggesting that tissue with a more severe initial injury is more likely to remain hypoperfused. Moreover, the nonreperfused regions had the highest risk of infarction, followed by new hypoperfused and reperfused regions.