Ying Wu1,2, Christine O'Brien3,
Christopher Glielmi4, Hongyan Du5, Robert Edelman2,3,
Ann Ragin6
1Radiology , NorthShore University
HealthSystem, Evanston, IL, United States; 2Radiology , University
of Chicago; 3Radiology, NorthShore University HealthSystem,
Evanston, IL, United States; 4Cardiovascular MR R&D, Siemens
Healthcare; 5NorthShore University HealthSystem Research
Institute; 6Radiology, Northwestern University
The
increased field strength at 3T significantly improved image quality of high
resolution Magnetization Transfer Images, while the increased scan variation
at higher field strength is a potential concern; this investigation indicated
that relative to 1.5T, the 3T scanner is conducive to more consistent MTR
measurement over time. Importantly, our findings in the human study indicate
excellent reproducibility in regions such as the hippocampus that are
critical regions for detecting early changes in Alzheimers disease and other
neurological disorders. Our results demonstrate the promising potential of
high resolution MT for clinical application.