Daniel Han-en Chang1, L Tugan Muftuler1,
Huali Wang2,3, Orhan Nalcioglu1, Min-Ying Lydia Su1
1Tu & Yuen Center for Functional
Onco-Imaging, University of California, Irvine, CA, United States; 2Dementia
Care Research Center, Peking University Institute of Mental Health, Beijing,
China; 3Key Laboratory for Mental Health, Ministry of Health,
Beijing, China
Subjects
with Alzheimers and mild cognitive impairment have decreased white matter
integrity in comparison to healthy controls, which can quantified as fractional
anisotropic (FA) and mean diffusivity (MD) values by DTI methods.
Tract-based-spatial-statistics (TBSS) is a frequently used robust method for
comparing FA maps between different subject groups; however, most published
studies analyzed subjects without excluding subjects with white matter
lesions, which may have an effect on FA and MD values. In order to examine
this possible effect, we excluded subjects with white matter lesions from our
study cohort and performed TBSS. Our results were consistent with what
literature reports.